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Category:
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7TM Receptors Dopamine ReceptorsD1-like Receptors
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Cat.No.
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Product Name
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2075 |
SKF 83822 hydrobromide
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Price and Availability
Click here for full price details of
SKF 83822
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Chemical Name:
6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-pro
penyl)-1H-3-benzazepine-7,8-diol hydrobromide |
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Biological Activity:
High affinity, selective dopamine D1-like
receptor agonist. Ki values are 3.2, 3.1, 186, 66, 335, 1167, 1251
and 1385 nM at recombinant D1, D5, D2, D3,
D4, 5-HT2A, α1A
and α1B
receptors respectively. Stimulates adenylyl cyclase (EC50 = 65 nM)
but not phosphoinositide hydrolysis. Induces extreme arousal and
hyperlocomotion following subcutaneous administration in monkeys.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Undie et al
(1994) Evidence for a distinct D1-like dopamine receptor that
couples to activation of phosphoinositide metabolism in brain. J.Neurochem. 62
2045. Peacock and Gerlach (2001) Aberrant behavioural effects of a
dopamine D1 receptor antagonist and agonist in monkeys: evidence of uncharted
dopamine D1 receptor actions. Biol.Psychiatry 50 501. O'Sullivan
et al (2004) SK&F 83822 distinguishes adenylyl cyclase from
phospholipase C-coupled D1-like receptors: behavioural topography.
Eur.J.Pharmacol. 486 273.
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View related products by Pharmacological Action
or by Research Area
Keywords: SKF 83822, Dopamine Receptors, Selective D1-like Agonist, SKF83822, Tocris Bioscience
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