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Category:
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7TM Receptors 5-HT Receptors5-HT2 Receptors5-HT2B
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Cat.No.
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Product Name
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1255 |
SDZ SER 082 fumarate
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Price and Availability
Click here for full price details of
SDZ SER 082 fumarate
Other Information:
Sold
with the permission of Novartis Pharma AG
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Chemical Name:
(+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindo
lo[1,7-bc][2,6]-naphthyridine fumarate |
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Biological Activity:
Selective
5-HT2B/2C receptor antagonist with low affinity for 5-HT1A
receptors. Inhibits [3H]-mesulergine binding to 5-HT2C receptors with a pKD of 7.8.
Inhibits 5-HT2B mediated responses in the rat fundus (pKB
= 7.34).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Nozulak et al (1995) (+)-cis
4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine: a
5-HT2C/2B receptor antagonist with low 5-HT2A receptor
affinity. J.Med.Chem. 38 28. Mora et al (1997) Role
of 5-HT2A and 5-HT2C receptor subtypes in the two types
of fear generated by the elevated T-maze. Pharmacol.Biochem.Behav. 58
1051. Kalkman et al (1998) Cataleptogenic effect of subtype
selective 5-HT receptor antagonists in the rat . Eur.J.Pharmacol. 343
201.
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Keywords: SDZ SER 082 Fumarate, 5-HT Receptors, Selective 5-HT2B / 2C Antagonist, SDZSER 082 Fumarate, Tocris Bioscience
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