SDZ NKT 343 | Peptides (Neuropeptides) | Highly Selective, Human NK1 Antagonist | SDZNKT 343

Category:

Cat.No.	Product Name
2394	SDZ NKT 343

Price and Availability

Click here for full price details of
SDZ NKT 343

Chemical Name: 1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3- (2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide

Biological Activity:

Highly selective human tachykinin NK₁ receptor antagonist (IC₅₀ values are 0.62 and 451 nM for human and rat receptors respectively) that displays > 130-fold selectivity over human NK₂ and NK₃ receptors. Potently antagonises SP-induced Ca²⁺ efflux in vitro and inhibits mechanical hyperalgesia in vivo.

Technical Data:

M.Wt:	579.65
Formula:	C₃₃H₃₃N₅O₅
Storage:	Store at +4°C
Solubility:	Soluble to 100 mM in DMSO and to 100 mM in Ethanol
Purity:	>98%
CAS No:	[180046-99-5]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Walpole et al (1998) Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor antagonist. Br.J.Pharmacol. 124 83. Walpole et al (1998) 2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N-methylamide (SDZ NKT 343), a potent human NK₁ tachykinin receptor antagonist with good oral analgesic activity in chronic pain models. J.Med.Chem. 41 3159. Campbell et al (1998) Selective neurokinin-1 receptor antagonists are anti-hyperalgesic in a model of neuropathic pain in the guinea-pig. Neuroscience. 87 527.

View related products by Pharmacological Action or by Research Area

Keywords: SDZ NKT 343, Peptides (Neuropeptides), Highly Selective, Human NK1 Antagonist, SDZNKT 343, Tocris Bioscience

Literature in this Area

Scientific Reviews

Tachykinin Receptor Compounds
Download PDF

Spring Specials

25% discount* on
selected Tocris products including:

Potent & selective NOP antagonist
Blocker of retinoic acid metabolism
Potent CCR1 receptor antagonist
Selective GnRH receptor antagonist
NMDA receptor antagonist

*Terms and conditions

New Products in this Area

	3009	Neuropeptide W-23 (human)
	Endogenous NPBW1 and NPBW2 receptor agonist
	2707	BIBP 3226 trifluoroacetate
	Mixed NPY Y₁ and NPFF receptor antagonist
	2603	PD 168368
	Selective neuromedin B receptor antagonist (NMB-R, BB₁)
	2602	PD 176252
	GRP (BB₂) and NMB (BB₁) receptor antagonist
	2717	BIM 189
	Bombesin antagonist
	2716	BIM 187
	Bombesin/GRP receptor agonist
	2690	Locustatachykinin I
	Insect tachykinin-related peptide (TRP)
	2576	Hemokinin 1 (human)
	Endogenous, selective NK₁ agonist

for new product e-alerts

User ID
Password