SC 19220 | Prostanoid Receptors | Selective EP1 Receptor Antagonist | SC19220

Category:

Cat.No.	Product Name
1206	SC 19220

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SC 19220

Chemical Name: 8-Chloro-dibenzo[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide

Biological Activity:

Selective EP₁ receptor antagonist (IC₅₀ = 6.7 μM for inhibition of [³H]-PGE₂ binding to EP₁ transfected COS cells).

Technical Data:

M.Wt:	331.76
Formula:	C₁₆H₁₄ClN₃O₃
Storage:	Store at RT
Solubility:	Soluble to 25 mM in Ethanol and to 100 mM in DMSO
Purity:	>99%
CAS No:	[19395-87-0]

Resources:

Certificate of Analysis / MSDS:

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References:

Sanner (1972) Dibenzoxapine hydrazides as prostaglandin antagonists. Intra-Science Chem.Rept. 6 1. Funk et al (1993) Cloning and expression of a cDNA for the human prostaglandin E receptor EP₁ subtype. J.Biol.Chem. 268 26767. Botella et al (1995) Receptor subtypes involved in dual effects induced by prostaglandin E₂in circular smooth muscle from dog colon. J.Pharmacol.Exp.Ther. 273 1008.

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Keywords: SC 19220, Prostanoid Receptors, Selective EP1 Receptor Antagonist, SC19220, Tocris Bioscience

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