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SCH 23390 hydrochloride
Chemical Name:(R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-te
trahydro-1H-3-benzazepine hydrochloride
Biological Activity:
Potent D1 antagonist (Ki
values are ~ 0.2, 0.3, ~ 1100, ~ 800 and ~ 3000 nM at D1, D5,
D2, D3 and D4 receptors respectively). Also an
agonist at 5-HT1C/2C receptors (Ki = 6.3 nM) in vitro.
Barnettet al (1986) Relative activities of SCH 23390 and its
analogs in three tests for D1/D1A dopamine receptor antagonism. Eur.J.Pharmacol. 128
249. Briggset al (1991) Activation of the 5-HT1C receptor
expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393.
Br.J.Pharmacol. 104 1038. Seeman and Van Tol (1994)
Dopamine receptor pharmacology. TiPS. 15 264.
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