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Category:
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Cellular Processes and Components Signal TransductionG Protein (Heterotrimeric)
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Cat.No.
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Product Name
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1400 |
SCH 202676 hydrobromide
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Price and Availability
Click here for full price details of
SCH 202676 hydrobromide
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Chemical Name:
N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanam
ine hydrobromide |
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Biological Activity:
Sulphydryl-reactive compound that inhibits
agonist and antagonist binding to G-protein-coupled receptors. Inhibits a
variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and
dopaminergic receptors (IC50 values are 0.1-1.8 μM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Fawzi et al (2001) SCH-202676: an
allosteric modulator of both agonist and antagonist binding to G
protein-coupled receptors. Mol.Pharmacol. 59 30. Gao et
al (2004) Effects of the allosteric modulator SCH-202676 on adenosine and
P2Y receptors. Life Sci. 74 3173. Lewandowicz et al
(2006) The 'allosteric modulator' SCH-202676 disrupts G protein-coupled
receptor function via sulphydryl-sensitive mechanisms. Br.J.Pharmacol. 147
422.
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Keywords: SCH 202676 Hydrobromide, Signal Transduction, Inhibitor Of Ligand Binding To G-protein-coupled Receptors, SCH202676 Hydrobromide, Tocris Bioscience
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Literature in this Area Cancer Research Guide | Our unique collection of more than 300 products related to cancer research, including the very latest exclusive research tools. | | Request Copy / View PDF |
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