SB 204741 | 5-HT Receptors | Potent, Selective 5-HT2B Antagonist | SB204741

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Cat.No.	Product Name
1372	SB 204741

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SB 204741

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Chemical Name: N-(1-Methyl-1H-indolyl-5-yl)-N''-(3-methyl-5-isothiazol yl)urea

Biological Activity:

Potent and selective 5-HT_2B receptor antagonist (pA₂ = 7.95). Displays ³ 135-fold selectivity over 5-HT_2C (pK_i = 5.82), 5-HT_2A (pK_i < 5.2), 5-HT_1A, _1D, _1E, 5-HT₃ and 5-HT₄ receptors.

Technical Data:

M.Wt:	286.35
Formula:	C₁₄H₁₄N₄OS
Storage:	Store at RT
Solubility:	Soluble to 100 mM in DMSO and to 20 mM in Ethanol
Purity:	>99%
CAS No:	[152239-46-8]

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References:

Forbes et al (1995) N-(1-Methyl-5-indolyl)-N¢-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT_2B receptor antagonist. J.Med.Chem. 38 855. Bonhaus et al (1995) The pharmacology and distribution of human 5-hydroxytryptamine_2B (5-HT_2B) receptor gene products: comparison with 5-HT_2A and 5-HT_2C receptors. Br.J.Pharmacol. 115 622. Glusa and Pertz (2000) Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT_2B receptors. Br.J.Pharmacol. 130 692.

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Keywords: SB 204741, 5-HT Receptors, Potent, Selective 5-HT2B Antagonist, SB204741, Tocris Bioscience

Literature in this Area

Scientific Reviews

5-HT Receptors & their Ligands
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