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Category: EnzymesarrowKinasesarrowMAPK/MAPKK
Cat.No. Product Name
1202 SB 203580
Price and Availability

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SB 203580

Other Information:

Sold with the permission of GlaxoSmithKline
Chemical Name: 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-i midazol-4-yl]pyridine

Biological Activity:

Selective inhibitor of p38 mitogen-activated protein kinase (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK3b and PKBα. Shown to inhibit interleukin-2-induced T-cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Also available as a water-soluble salt (Cat. No. 1402).

Technical Data:

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M.Wt: 377.44
Formula: C21H16FN3OS
Storage: Desiccate at +4°C
Solubility: Soluble to 25 mM in DMSO and to 100 mM in 1eq. HCl
Purity: >99%
CAS No: [152121-47-6]

Resources:

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    References:

    Cuenda et al (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364 229. Saklatvala et al (1996) Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen on a thromboxane analogue. J.Biol.Chem. 271 6586. Borsch-Haubold et al (1998) Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. J.Biol.Chem. 273 28766. Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95.
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    Keywords: SB 203580, Kinases, Selective Inhibitor Of P38 MAPK, SB203580, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    Function & Modulation of MAP Kinase Pathways
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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