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Category: EnzymesarrowKinasesarrowProtein Kinase C
Cat.No. Product Name
1610 Rottlerin
Price and Availability

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Rottlerin
Chemical Name: 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzop yran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophe none

Biological Activity:

Originally reported to inhibit PKC isoforms, with selectivity for PKCδ (Ki values are 30, 42, 40, 3-6, 100, and 100 μM for α, β, γ, δ, e, l respectively). Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC50 values are 1.9 and 5 μM respectively). Also shown to act as a direct mitochondrial uncoupler.

Technical Data:

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M.Wt: 516.55
Formula: C30H28O8
Storage: Store at +4°C
Solubility: Soluble to 2 mM in Ethanol and to 100 mM in DMSO
CAS No: [82-08-6]

Resources:

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    • Certificate of Analysis / MSDS:

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    References:

    Gschwendt et al (1994) Rottlerin, a novel protein kinase inhibitor. Biochem.Biophys.Res.Comm. 199 93. Way et al (2000) Identification of PKC-isoform-specific biological actions using pharmacological approaches. TiPS 21 181. Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95. Zhang et al (2007) Neuroprotective effect of protein kinase Cδ inhibitor rottlerin in cell culture and animal models of Parkinson's disease. J.Pharmacol.Exp.Ther. 322 913.
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    Keywords: Rottlerin, Kinases, Reported PKCd Inhibitor, Tocris Bioscience
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