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Category: EnzymesarrowPhosphodiesterases
Cat.No. Product Name
1350 (S)-(+)-Rolipram
Price and Availability

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(S)-(+)-Rolipram
Chemical Name: (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2 -one

Biological Activity:

Less active enantiomer of the PDE4 inhibitor rolipram (Cat. No. 0905).

Technical Data:

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M.Wt: 275.35
Formula: C16H21NO3
Storage: Store at RT
Solubility: Soluble to 100 mM in DMSO
Purity: >99%
CAS No: [85416-73-5]

Resources:

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    References:

    Schneider et al (1986) Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur.J.Pharmacol. 127 105. Owens et al (1997) Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells. Biochem.J. 326 53. Ohsawa et al (1998) Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains. Jpn.J.Pharmacol. 77 147.
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    Keywords: (S)-(+)-Rolipram, Phosphodiesterases, Less Active Enantiomer Of Cat. No. 0905, Rolipram, Tocris Bioscience

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