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Category: EnzymesarrowKinasesarrowBroad Spectrum Protein Kinase Inhibitors
Cat.No. Product Name
2002 Ro 31-8220 mesylate
Alternative name(s): Bisindolylmaleimide IX
Price and Availability

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Ro 31-8220
Chemical Name: 3-[3-[2,5-Dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo- 1H-pyrrol-3-yl]-1H-indol-1-yl]propyl carbamimidothioic acid ester mesylate

Biological Activity:

Protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na+ channels in the micromolar range.

Technical Data:

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M.Wt: 553.65
Formula: C25H23N5O2S.CH3SO3H
Storage: Desiccate at -20°C
Solubility: Soluble to 100 mM in DMSO and to 5 mM in Ethanol
Purity: >98%
CAS No: [125314-64-9]

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    References:

    Davis et al (1989) Potent, selective inhibitors of protein kinase C. FEBS Lett. 259 61. Standaert et al (1999) RO 31-8220 activates c-Jun N-terminal kinase and glycogen synthase in rat adipocytes and L6 myotubes. Comparison to actions of insulin. Endocrinol. 150 2145. Lingameneni et al (2000) Inhibition of voltage-dependent sodium channels by Ro 31-8220, a 'specific' protein kinase C inhibitor. FEBS Lett. 473 265. Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95.
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    Keywords: Ro 31-8220, Kinases, Protein Kinase Inhibitor, Bisindolylmaleimide IX, Ro31-8220, Tocris Bioscience
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