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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowNMDA SitearrowAntagonists
Cat.No. Product Name
2005 Ro 04-5595 hydrochloride
Price and Availability

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Ro 04-5595
Chemical Name: 1-[2-(4-Chlorophenyl)ethyl]-1,2,3,4-tetrahydro-6-methox y-2-methyl-7-isoquinolinol hydrochloride

Biological Activity:

Selective antagonist for NR2B-containing NMDA receptors (Ki = 31 nM).

Technical Data:

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M.Wt: 368.3
Formula: C19H22ClNO2.HCl
Storage: Desiccate at +4°C
Solubility: Soluble to 15 mM in Water
Purity: >98%
CAS No: [194089-07-1]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Mutel et al (1998) In vitro binding properties in rat brain of [3H] Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits. J.Neurochem. 70 2147
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    Keywords: Ro 04-5595, Ligand-gated Ion Channels, Selective NR2B Antagonist, Ro04-5595, Tocris Bioscience
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