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Retinoic acid
Chemical Name:3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4
E,6E,8E,-nonatetraenoic acid
Biological Activity:
Endogenous agonist for retinoic acid receptors. Also positively
modulates PPARδ receptors (Kd
= 17 nM). Controls the differentiation and proliferation of many types of
cells.
Merck
12 8333. Lofan (1980) Effects of vitamin A and its
analogues (retinoids) on normal and neoplastic cells. Biochem.Biophys.Acta 605
33. Sanquer and Gilchrest (1994) Characterisation of human cellular
retinoic acid binding proteins-1 and -2: ligand binding affinities and
distribution in skin. Biochem.Biophys.Acta 311 86. Leeet
al (1998) All-trans-retinoic acid inhibits jun N-terminal
kinase-dependent signalling pathways. J.Biol.Chem. 273 7066. Shawet al (2003) Retinoic acid is a high affinity selective ligand for the
peroxisome proliferator-activated receptor β/δ.
J.Biol.Chem. 278 41589.
