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Remoxipride hydrochloride
Chemical Name:(S)-(-)-3-Bromo-N-[(1-ethyl-2-pyrrolidinyl0methyl]2,6-d
imethoxybenzamide hydrochloride
Biological Activity:
Standard D2 receptor
antagonist showing good selectivity over D3 and D4
receptors (Ki values are ~ 300, ~ 1600, and ~ 2800 nM for D2,
D3 and D4 receptors respectively). In vivo remoxipride is
an antipsychotic which does not cause extrapyramidal side effects and is
50-fold more potent than sulpiride in antagonising the effects of apomorphine
in the rat.
Sedvall(1990) Development of a
new antipsychotic remoxipride. Acta Psychiatr.Scand.Suppl. No. 82 Vol. 358. Mohell
et al (1993) Binding characteristics of remoxipride and its
metabolites to dopamine D2 and D3 receptors. Eur.J.Pharmacol. 238 121. Seeman
and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15
264. Ahleniuset al (1997) In
vivo effects of remoxipride and aromatic ring metabolites in the rat.
J.Pharmacol.Exp.Ther. 283 1356.
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