Rapamycin | Kinases | MTOR Inhibitor; Immunosuppressant

Category:

Cat.No.	Product Name
1292	Rapamycin

Price and Availability

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Rapamycin

Chemical Name: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34 aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hex adecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydro xy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy- 6,8,12,14,20,26-hexamethyl-23,27-ep

Biological Activity:

Antifungal and immunosuppressant. Specific inhibitor of mTOR (mammalian target of Rapamycin). Complexes with FKBP-12 and binds mTOR inhibiting its activity. Inhibits interleukin-2-induced phosphorylation and activation of p70 S6 kinase.

Technical Data:

M.Wt:	914.18
Formula:	C₅₁H₇₉NO₁₃
Storage:	Desiccate at -20°C
Solubility:	Soluble to 100 mM in Ethanol and to 50 mM in DMSO
Purity:	>98%
CAS No:	[53123-88-9]

Resources:

Certificate of Analysis / MSDS:

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Product/Material Safety Data Sheet: View current batch

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References:

Merck Index 12 8288. Chang et al (1991) FK506 and rapamycin: novel pharmacological probes of the immune response. TiPS 12 218. Kuo et al (1992) Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 358 70. Kobayashi et al (2007) Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis. Cancer Sci. 98 726.

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Keywords: Rapamycin, Kinases, MTOR Inhibitor; Immunosuppressant, Tocris Bioscience

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Signal Transduction Guide

	A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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Product Feature

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