|
Category:
|
Cellular Processes and Components Cell MetabolismLipid Metabolism
|
|
Cat.No.
|
Product Name
|
|
2194 |
R 59-022
|
|
|
|
Price and Availability
Click here for full price details of
R 59-022
|
|
Chemical Name:
6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl
]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one |
|
|
Biological Activity:
Diacylglycerol (DAG) kinase inhibitor (IC50
= 2.8 μM);
increases protein kinase C activity. Potentiates thrombin-induced platelet
aggregation and induces neutrophil chemotaxis. Inhibits U46619-induced
contractions in mouse aorta and porcine coronary artery.
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
|
|
|
References:
de Chaffoy de Courcelles et
al (1985) R 59 022, a diacylglycerol kinase inhibitor. Its effect on
diacylglycerol and thrombin-induced C kinase activation in the intact platelet.
J.Biol.Chem. 260 15762. Nunn and Watson (1987) A
diacylglyerol kinase inhibitor, R59022, potentiates secretion by and
aggregation of thrombin-stimulated human platelets. Biochem.J. 243
809. Boonen et al (1993) Neutrophil chemotaxis induced by the
diacylglycerol kinase inhibitor R59022. Biochim.Biophys.Acta 1178
97. Nobe et al (2004) Novel diacylglycerol kinase inhibitor
selectively suppressed an U46619-induced enhancement of mouse portal vein
contraction under high glucose conditions. Br.J.Pharmacol. 143
166.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: R 59-022, Cell Metabolism, Diacylglycerol Kinase Inhibitor; Increases PKC Activity, R59-022, Tocris Bioscience
|
|
Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
| “Tocris is to be congratulated for continuing to meet the current demand for a rapid and reliable source of high-quality compounds that are urgently needed as pharmacological tools by a growing international population of cannabinoid researchers..” Researcher, University of Aberdeen, UK |
|
