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Category:
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Nuclear Receptors Mineralocorticoid Receptor
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Cat.No.
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Product Name
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1672 |
RU 28318, potassium salt
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| Alternative name(s): |
Oxprenoate
potassium |
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Price and Availability
Click here for full price details of
RU 28318
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Chemical Name:
(7a,17a)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carbox
ylic acid, potassium salt |
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Biological Activity:
Potent and selective antagonist for the mineralocorticoid receptor
(MR). Inhibits aldosterone production and secretion, and selectively decreases
ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases
blood pressure in female rats following central administration in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Perroteau et al (1984) The effect of
the antimineralocorticoid RU 28318 on aldosterone biosythesis in vitro.
J.Steroid Biochem. 20 853. Kim et al (1998)
Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and
glucocorticoid receptor antagonists, respectively: receptor measures and
functional studies. J.Steroid Biochem.Molec.Biol. 67 213. Rahmouni
et al (1999) Cardiovascular and renal effects of central administration
of a mineralocorticoid receptor antagonist in concious female rats.
Eur.J.Pharmacol. 385 199.
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Keywords: RU 28318, Mineralocorticoid Receptor, Potent, Selective Mineralocorticoid Receptor Antagonist, Oxprenoate Potassium, RU28318, Tocris Bioscience
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