Click here for full price details of
RS 67506 hydrochloride
Other Information:
Sold
with the permission of Roche Bioscience
Chemical Name:1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulph
onylamino)ethyl-4-piperidinyl]-1-propanone
hydrochloride
Biological Activity:
A potent and selective
5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4
sites in guinea pig striatum, but < 6.0 at several other receptors including
5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3.
It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.
Eglen et al (1995) Pharmacological characterization of two
novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in
vitro and in vivo. Br.J.Pharmacol. 115 1387. Eglenet al (1995) Central 5-HT4 receptors. TiPS 16 391.
Fontanaet al (1997) The effects of novel, selective
5-hydroxytryptamine (5HT)4 ligands in rat spatial navigation.
Neuropharmacology 36 689.
Atypical antipsychotic agent that displays 5-HT2A receptor antagonism. Also displays high affinity at D2 receptors (Ki values are 0.4 and 3.13 nM for 5-HT2A and D2 receptors respectively).
