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Chemical Name:1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piper
idinyl]-1-propanone hydrochloride
Biological Activity:
A potent and highly selective 5-HT4 partial agonist,
with pKi values of 8.7 at 5-HT4 sites in guinea pig
striatum and > 6 at various other receptors, including 5-HT1A, 1D,
2A, 2C, D1, D2 and M1-3.
Active in vivo, with an intrinsic activity relative to 5-HT of 0.5.
Eglen et al (1995) Pharmacological characterization of two
novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in
vitro and in vivo. Br.J.Pharmacol. 115 1387. Eglenet al (1995) Central 5-HT4 receptors. TiPS 16 391.
Fontanaet al (1997) The effects of novel, selective
5-hydroxytryptamine (5HT)4 receptor ligands in rat spatial
navigation. Neuropharmacology 36 689.
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