RS 504393 | Chemokine Receptors | Highly Selective CCR2 Chemokine Receptor Antagonist | RS504393

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Cat.No.	Product Name
2517	RS 504393

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RS 504393

Chemical Name: 6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spi ro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one

Biological Activity:

Extremely selective CCR2 chemokine receptor antagonist (IC₅₀ values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC₅₀ = 330 nM) and ischaemia-reperfusion injury in kidneys.

Technical Data:

M.Wt:	417.5
Formula:	C₂₅H₂₇N₃O₃
Storage:	Store at +4°C
Solubility:	Soluble to 100 mM in DMSO
Purity:	>99%
CAS No:	[300816-15-3]

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Certificate of Analysis / MSDS:

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References:

Mirzadegan et al (2000) Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists. J.Biol.Chem. 275 25562. Furuichi et al (2003) CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J.Am.Soc.Nephrol. 14 2503. Kitagawa et al (2004) Blockade of CCR2 ameliorates progressive fibrosis in kidney. Am.J.Pathol. 165 237.

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Keywords: RS 504393, Chemokine Receptors, Highly Selective CCR2 Chemokine Receptor Antagonist, RS504393, Tocris Bioscience

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