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Category:
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7TM Receptors Adrenergic ReceptorsAlpha-1 ReceptorsAntagonists
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Cat.No.
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Product Name
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0985 |
RS 17053 hydrochloride
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Price and Availability
Click here for full price details of
RS 17053 hydrochloride
Other Information:
Sold with the permission of Roche Bioscience
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Chemical Name:
(N-[2-(2-Cyclopropylmethoxyphenoxy)ethyl]-5-chloro-a,a-
dimethyl-1H-indole-3-ethanamine) hydrochloride |
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Biological Activity:
α1A-adrenoceptor antagonist,
with very high affinity for α1A receptors (pKi
and pA2 estimates of 9.1-9.9) and a 30-100 fold selectivity over the
α1B and α1D subtypes (pKi
and pA2 estimates 7.7-7.8).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Ford et al (1995) Do α 1A (α 1C)-adrenoceptors (AR) mediate prostatic
smooth muscle contraction in man? Studies with a novel, selective α 1A-AR antagonist, RS 17053. Br.J.Pharmacol. 114 C25. Ford
et al (1996) RS 17053
(N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α ,α -dimethyl-1H-indole-3-ethanamine
hydrochloride, a selective α 1A-adrenoceptor antagonist,
displays low affinity for functional α 1-adrenoceptors in human
prostate: implications for adrenoceptor classification. Mol.Pharmacol. 49
209. Marshall et al (1996) Different subtypes of α 1A-adrenoceptor mediating contraction of rat epididymal vas
deferens, rat hepatic portal vein and human prostate distinguished by the
antagonist RS 17053. Br.J.Pharmacol. 119 407.
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Keywords: RS 17053 Hydrochloride, Adrenergic Receptors, A1A Antagonist, RS17053 Hydrochloride, Tocris Bioscience
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