Nootropic that displays cognitive enhancing
properties. Proposed to enchance neurotransmission via modulation of ion flux;
potentiates Na+ influx through AMPA receptors. Facilitates
efficiency of cholinergic neurotransmission at muscarinic receptors.
Vernon and Sorkin (1991)
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Gouliaev and Senning (1994) Piracetam and other structurally related
nootropics. Brain Res. Brain Res.Rev. 19 180. Winbald
(2005) Piracetam: a review of pharmacological properties and clinical uses. CNS
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Displays 26-fold and > 440-fold selectivity over kainate and NMDA receptors respectively. Neuro-protective; delays neuronal death in a global ischaemia model and cerebral infarction in a focal ischaemia model.