2-Phenylmelatonin | Melatonin (MT) Receptors | Potent Melatonin Agonist | 2Phenylmelatonin

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Cat.No.	Product Name
0680	2-Phenylmelatonin

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2-Phenylmelatonin

Chemical Name: N-[2-(5-Methoxy-2-phenylindol-3-yl)ethyl]acetamide

Biological Activity:

Highly potent melatonin agonist; displays higher affinity and greater potency than melatonin itself. The EC₅₀ values for G protein activation in MT₁ and MT₂-transfected cells are 65 and 58 pM respectively.

Technical Data:

M.Wt:	308.38
Formula:	C₁₉H₂₀N₂O₂
Storage:	Desiccate at +4°C
Solubility:	Soluble to 100 mM in Ethanol
Purity:	>98%
CAS No:	[151889-03-1]

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References:

Spadoni et al (1993) 2-Substituted 5-methoxy-N-acetyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity. J.Med.Chem. 36 4069. Nonno et al (1998) Pharmacological characterization of the human melatonin Mel_1a receptor following stable transfection into NIH3T3 cells. Br.J.Pharmacol. 124 485. Nonno et al (1999) Ligand efficacy and potency at recombinant human MT₂ melatonin receptors: evidence for agonist activity of some mt₁-antagonists. Br.J.Pharmacol. 127 1288.

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Keywords: 2-Phenylmelatonin, Melatonin (MT) Receptors, Potent Melatonin Agonist, 2Phenylmelatonin, Tocris Bioscience

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Melatonin Receptors
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