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Category:
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Enzymes DeacetylasesHistone Deacetylase
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Cat.No.
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Product Name
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2682 |
4-Phenylbutyrate, sodium
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| Alternative name(s): |
4-PB |
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Price and Availability
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4-Phenylbutyrate, sodium
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Chemical Name:
4-Phenylbutyric acid, sodium salt |
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Biological Activity:
Histone deacetylase inhibitor that
displays anticancer activity. Inhibits cell proliferation, invasion and
migration and induces apoptosis in glioma cells. Also inhibits protein
isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin
through transcriptional activation of the γ-globin
gene and affects hPPARγ activation.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Engelhard et al (1998) Inhibitory effects of phenylbutyrate on the
proliferation, morphology, migration and invasiveness of malignant glioma
cells. J.Neuro-Oncol. 37 97. Appelskog et al (2004)
Histone deacetylase inhibitor 4-phenylbutyrate suppresses GADPH mRNA expression
in glioma cells. Int.J.Oncol. 24 1419. Ammerpohl et al
(2007) Complementary effects of HDAC inhibitor 4-PB on gap junction
communication and cellular export mechanisms support restoration of
chemosensitivity of PDAC cells. Br.J.Cancer 96 73.
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Keywords: 4-Phenylbutyrate, Sodium, Deacetylases, Histone Deacetylase Inhibitor, 4-PB, 4Phenylbutyrate, Sodium, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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