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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGABAA and GABAC ReceptorsarrowMiscellaneous GABA
Cat.No. Product Name
2687 Pentylenetetrazole
Alternative name(s): PTZ
Price and Availability

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Pentylenetetrazole
Chemical Name: 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine

Biological Activity:

CNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.

Technical Data:

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M.Wt: 138.17
Formula: C6H10N4
Storage: Store at -20°C
Solubility: Soluble to 100 mM in Water and to 100 mM in DMSO
Purity: >99%
CAS No: [54-95-5]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Rocha et al (1996) Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems. Epilepsy Res. 26 105. Walsh et al (1999) Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J.Pharmacol.Exp.Ther. 289 1626. Dhir et al (2006) Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action. Prog.Neuro-Psychopharm.Biol.Psychiat. 30 1478.
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    Keywords: Pentylenetetrazole, Ligand-gated Ion Channels, CNS Stimulant, PTZ, Tocris Bioscience
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