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Category:
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7TM Receptors Adenosine ReceptorsAntagonists
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Cat.No.
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Product Name
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2009 |
PSB 1115 potassium salt
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Price and Availability
Click here for full price details of
PSB 1115
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Chemical Name:
4-(2,3,6,7-Tetrahydro-2,6-dioxo-1-propyl-1H-purin-8-yl)
-benzenesulfonic acid potassium salt |
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Biological Activity:
Highly selective, water-soluble, human A2B
adenosine receptor antagonist. Ki values are 53.4, > 10000 and
> 10000 nM at human A2B, A1 and A3
receptors respectively. Also selective versus rat A1 and A2A
receptors (Ki values are 2200 and 24000 nM respectively). Produces
potent analgesic effects in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Muller et al (1998)
8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine
receptor antagonists. Bioorg.Med.Chem. 6 707. Hayallah et
al (2002) 1,8-Disubstituted xanthine derivatives: synthesis of potent A2B-selective
adenosine receptor antagonists. J.Med.Chem. 45 1500. Abo-Salem
et al (2004) Antinociceptive effects of novel A2B adenosine
receptor antagonists. J.Pharmacol.Exp.Ther. 308 358. Yan and
Muller (2004) Preparation, properties, reactions, and adenosine receptor
affinities of sulfophenylxanthine nitrophenyl esters: toward the development of
sulfonic acid prodrugs with peroral bioavailability. J.Med.Chem. 47
1031.
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Keywords: PSB 1115, Adenosine Receptors, Selective Human A2B Receptor Antagonist; Water-soluble, PSB1115, Tocris Bioscience
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