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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowNMDA SitearrowAntagonists
Cat.No. Product Name
2530

PPDA

Price and Availability

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PPDA
Chemical Name: (2S*,3R*)-1-(Phenanthren-2-carbonyl)piperazine-2,3-dica rboxylic acid

Biological Activity:

Subtype-selective NMDA receptor antagonist that preferentially binds to NR2C/NR2D-containing receptors (Ki values are 0.096, 0.125, 0.31 and 0.55 μM for NR2C, NR2D, NR2B and NR2A subunits respectively).

Technical Data:

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M.Wt: 378.38
Formula: C21H18N2O5
Storage: Store at +4°C
Solubility: Soluble to 50 mM in 2eq. NaOH and to 100 mM in DMSO
Purity: >98%

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    References:

    Feng et al (2004) Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid. Br.J.Pharmacol. 141 508. Morley et al (2005) Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J.Med.Chem. 48 2627. Kinarsky et al (2005) Identification of subunit- and antagonist-specific amino acid residues in the N-methyl-D-aspartate receptor glutamate-binding pocket. J.Pharmacol.Exp.Ther. 313 1066.
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    Keywords: PPDA, Ligand-gated Ion Channels, Subtype-selective NR2C / NR2D Antagonist, Tocris Bioscience
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