Tocris Bioscience
 Welcome to Tocris

Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowP2X ReceptorsarrowAntagonists
Cat.No. Product Name
0625

PPADS tetrasodium salt  

Price and Availability

Click here for full price details of
PPADS tetrasodium salt
Chemical Name: Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium salt

Biological Activity:

A non-selective P2 purinergic antagonist. Blocks recombinant P2X1, P2X2, P2X3, P2X5 (IC50 = 1 - 2.6 μM), native P2Y2-like (IC50 ~ 0.9 μM), and recombinant P2Y4 (IC50 ~ 15 μM) receptors.

Technical Data:

 Click here for more information on batch specific data
M.Wt: 599.3
Formula: C14H10N3Na4O12PS2
Storage: Desiccate at -20°C
Solubility: Soluble to 100 mM in Water
CAS No: [149017-66-3]

Resources:

    		•

    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    For specific/earlier batch please select:  
    Product/Material Safety Data Sheet: View current batch
    For specific/earlier batch please select:  

    References:

    Lambrecht et al (1992) PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. Eur.J.Pharmacol. 217 217. McLaren et al (1994) Investigation of the actions of PPADS, a novel P2x-purinoceptor antagonist, in the guinea-pig isolated vas deferens. Br.J.Pharmacol. 111 913. Ziganshin et al (1994) Selective antagonism by PPADS at P2x-purinoceptors in rabbit isolated blood vessels. Br.J.Pharmacol. 111 93. Ralevic and Burnstock (1998) Receptors for purines and pyrimidines. Pharmacol.Rev. 50 413.
    View related products by Pharmacological Action or by Research Area

    Keywords: PPADS Tetrasodium Salt, Ligand-gated Ion Channels, P2 Purinergic Antagonist, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    Nucleotide & Nucleoside Receptors
    Download PDF
    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
    View PDF
    First-Class Technical Expertise
    At Tocris we understand that planning an experiment is complicated and that it is important to be able to interact with knowledgeable people who care about helping you find the products and information you need.

    Our specialist scientists provide the highest level of service for every enquiry, fully researching each one and supplying the most accurate response, quickly.

    We encourage our customers to contact us; no question is too small or insignificant.
    New Products in this Area

     2557Phencyclidine hydrochloride
     Non-competitive NMDA receptor antagonist
     3087Lorazepam
     Acts at the benzodiazepine modulatory site
     2733U 90042
     GABAA receptor ligand
     1340α-Conotoxin MII
     

    Potent α3β2 and β3 subunit selective nicotinic antagonist

     3046Alphaxalone
     Direct activator and potentiator of GABAA
     2980CX 546
     AMPA receptor potentiator
     3071Dextromethorphan hydrobromide
     NMDA receptor antagonist
     3083DMCM hydrochloride
     Benzodiazepine inverse agonist
     2905TB 21007
     α5-selective GABAA inverse agonist
     2738Org 20599
     Positive allosteric modulator and direct agonist of GABAA receptors
     2805Diazepam
     Acts at the benzodiazepine modulatory site
     2832Midazolam hydrochloride
     Benzodiazepine agonist
     2972A 438079 hydrochloride
     Competitve P2X7 antagonist
     2736Sazetidine A dihydrochloride
     Subtype-selective α4β2 receptor desensitiser
     2929PEPA
     Allosteric potentiator of AMPA receptor desensitisation
     2973Piracetam
     Nootropic; modulates Na+-flux at AMPA receptors
     2734U 89843A
     Positive allosteric modulator of GABAA
     2903Granisetron hydrochloride
     5-HT3 antagonist
     2782TCS 46b
     Orally active, subtype-selective NR1A/NR2B antagonist
     2931Spinorphin
     Potent P2X3 antagonist
     2851Nefiracetam
     Cognitive enhancer
     2770Philanthotoxin 74
     GluR1/2 selective AMPA antagonist
     2891Ondansetron hydrochloride
     Selective 5-HT3 antagonist
     2820(+)-Tubocurarine chloride
     Nicotinic receptor antagonist
     2843Mecamylamine hydrochloride
     Non-competitive nicotinic receptor antagonist
     2810Carbamoylcholine chloride
     Cholinergic receptor agonist
     1521LY 233053
     Competitive NMDA receptor antagonist
     2745U 93631
     GABAA receptor antagonist
     2785Strychnine hydrochloride
     Competitive glycine receptor antagonist
     2737TC 2559 difumarate
     Selective partial agonist at α4β2 receptors
     2809Acetylcholine chloride
     Endogenous neurotransmitter
     268117-PA
     Antagonist of neurosteroid potentiation and direct gating of GABAA
     2722Catestatin
     Inhibitor of nicotinic cholinergic-stimulated catecholamine secretion
     2701YM 90K hydrochloride
     Selective AMPA antagonist
    Sign-up for new product e-alerts
    Log In / Register

    User ID
    Password
    If you are not registered with us Create Account
    Home | About | Contact | Distributors | Environment | Glossary | Ordering | Target Detective | Terms & Conditions | Services | Site Map