PNU 96415E | Dopamine Receptors | D4 & 5-HT2A Antagonist; Antipsychotic | PNU96415E

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Cat.No.	Product Name
2735	PNU 96415E

Price and Availability

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PNU 96415E

Chemical Name: 1-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluo rophenyl)piperazine dihydrochloride

Biological Activity:

Antipsychotic agent. Displays high affinity for dopamine D₄ and serotonergic 5-HT_2A receptors and relatively weak affinity at D₂ receptors (K_i values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D₄, 5-HT_2A, 5-HT_1A, α₁, D₂, D₃, D₁, α₂ and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonises d-amphetamine-induced locomotor stimulation in rats.

Technical Data:

M.Wt:	413.36
Formula:	C₂₁H₂₅FN₂O.2HCl
Storage:	Desiccate at RT
Solubility:	Soluble to 10 mM in Water
Purity:	>98%
CAS No:	[170856-41-4]

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Certificate of Analysis / MSDS:

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References:

Tang et al (1997) PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties. J.Pharmacol.Exp.Ther. 281 440. Goudie et al (1998) Discriminative stimulus properties of the atypical neuroleptic clozapine in rats: tests with subtype selective receptor ligands. Behav.Pharmacol. 9 699.

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Keywords: PNU 96415E, Dopamine Receptors, D4 & 5-HT2A Antagonist; Antipsychotic, PNU96415E, Tocris Bioscience

Literature in this Area

Scientific Reviews

Dopamine Receptors
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Purity To Rely On

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This accurate purity data is available on a batch-specific basis for every product via our website. At Tocris we work hard to ensure that we always supply to the highest possible standards of purity.

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