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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowAcetylcholine (Nicotinic) ReceptorsarrowOther Acetylcholine
Cat.No. Product Name
2498 PNU 120596
Price and Availability

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PNU 120596
Chemical Name: N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazo lyl)-urea

Biological Activity:

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (EC50 = 216 nM), with no detectable effect on α4β2, α3β4 and α9α10 receptors. Active in vivo following systemic administration.

Technical Data:

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M.Wt: 311.72
Formula: C13H14ClN3O4
Storage: Desiccate at +4°C
Solubility: Soluble to 100 mM in DMSO
Purity: >99%
CAS No: [501925-31-1]

Resources:

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    References:

    Hurst et al (2005) A novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J.Neurosci. 25 4396.
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    Keywords: PNU 120596, Ligand-gated Ion Channels, Positive Allosteric Modulator Of A7 NAChR; Active In Vivo, PNU120596, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    Nicotinic ACh Receptors
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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    Product Feature
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