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Category: EnzymesarrowKinasesarrowProtein Kinase A
Cat.No. Product Name
2546 PKI 14-22 amide, myristoylated
Alternative name(s): Protein kinase inhibitor-(14-22)-amide, myristoylated
Price and Availability

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PKI 14-22 amide, myristoylated

Biological Activity:

Cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).

Technical Data:

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M.Wt: 1209.5
Formula: C53H100N20O12
Storage: Desiccate at -20°C
CAS No: [201422-03-9]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein. J.Biol.Chem. 264 8802. Zheng et al (2000) Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. J.Biol.Chem. 275 31747. Farrow et al (2003) Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 134 197.
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    Keywords: PKI 14-22 Amide, Myristoylated, Kinases, Cell-permeable Protein Kinase A Inhibitor, Protein Kinase Inhibitor-(14-22)-amide, Myristoylated, PKI14-22 Amide, Myristoylated, Tocris Bioscience
    Literature in this Area
    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
    View PDF
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