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Category:
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Enzymes KinasesPI 3-Kinase
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Cat.No.
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Product Name
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2930 |
PI 103 hydrochloride
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Price and Availability
Click here for full price details of
PI 103 hydrochloride
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Chemical Name:
3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidi
n-2-yl]phenol hydrochloride |
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Biological Activity:
Inhibitor of DNA-PK, PI 3-kinase (p110α) and mTOR
(IC50 values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and
2300 nM for DNA-PK, p110α,
mTORC1, PI3KC2β,
p110δ,
mTORC2, p110β,
p110γ,
ATR, ATM, PI3KC2α
and hsVPS34 respectively). Inhibits growth of human tumour xenografts in mice
in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Fan et al (2006) A dual
PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer cell 9
341. Knight et al (2006) A pharmacological map of the PI3-K
family defines a role for p110α
in insulin signaling. Cell 125 733. Raynaud et al
(2007) Pharmacologic characterization of a potent inhibitor of class I
phosphatidylinositol 3-kinase. Cancer Res. 67 5840.
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View related products by Pharmacological Action
or by Research Area
Keywords: PI 103 Hydrochloride, Kinases, Inhibitor Of PI 3-kinase, MTOR & DNA-PK, PI103 Hydrochloride, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Product Feature
Kinase Inhibitors
Key kinase Inhibitors available from Tocris include:
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