PHTPP | Estrogen & Related Receptors | Selective ERb Antagonist

Category:

Cat.No.	Product Name
2662	PHTPP

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PHTPP

Chemical Name: 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyri midin-3-yl]phenol

Biological Activity:

Selective estrogen ERβ receptor antagonist that displays 36-fold selectivity over ERα. Exhibits full antagonism at ERβ in a cotransfection assay in human endometrial cancer cells (HEC-1), with minimal effects on ERα.

Technical Data:

M.Wt:	423.31
Formula:	_C20H11F6N3O
Storage:	Store at RT
Solubility:	Soluble to 33 mM in DMSO and to 100 mM in Ethanol
Purity:	>99%
CAS No:	[805239-56-9]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Compton et al (2004) Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor β antagonist activity. J.Med.Chem. 47 5872. Compton et al (2005) Erratum. J.Med.Chem. 48 2724.

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Keywords: PHTPP, Estrogen & Related Receptors, Selective ERb Antagonist, Tocris Bioscience

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Product Feature

Estrogen Receptors

Key estrogen receptors available from Tocris include:

2662 PHTPP

Selective ERβ antagonist

2676 Y 134

Selective estrogen receptor modulator

2183 ZK 164015

Potent estrogen receptor silent antagonist

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