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Category:
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7TM Receptors Peptides (Calcium-metabolic Hormones)CGRP and Related Receptors
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Cat.No.
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Product Name
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2080 |
PHM 27 (human)
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| Alternative name(s): |
Peptide
histidine methionine 27 (human) |
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Human
PHI 27 |
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Price and Availability
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PHM 27 (human)
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Biological Activity:
Endogenous
peptide product of human prepro-VIP and analogue of porcine PHI-27; potent
agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic
mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced
glucose-induced insulin secretion.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Itoh et al (1983) Human preprovasoactive intestinal polypeptide
contains a novel PHI-27-like peptide, PHM-27. Nature 304 547. Kato
et al (1994) Transgenic mice overexpressing human vasoactive intestinal
peptide (VIP) gene in pancreatic β cells. J.Biol.Chem. 269
21223. Ma et al (2004) Discovery of novel peptide/receptor
interactions: identification of PHM-27 as a potent agonist of the human
calcitonin receptor. Biochem.Pharmacol. 67 1279.
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or by Research Area
Keywords: PHM 27 (human), Peptides (Calcium-metabolic Hormones), Potent Calcitonin Receptor Agonist; Endogenous Analogue Of Human VIP, Peptide Histidine Methionine 27 (human), Human PHI 27, PHM27 (human), Tocris Bioscience
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