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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowAMPA / Kainate SelectivearrowDesensitization Modulators
Cat.No. Product Name
2929 PEPA
Price and Availability

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PEPA
Chemical Name: 2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio ]phenoxy]acetamide

Biological Activity:

Novel allosteric potentiator of AMPA receptor desensitisation. Slows the rate of onset of desensitisation and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluR3/4 > GluR1) and splice variant (flop > flip) selectivity. Ameliorates post-ischaemic memory impairment in rats following i.v. administration.

Technical Data:

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M.Wt: 402.44
Formula: C16H16F2N2O4S2
Storage: Store at RT
Solubility: Soluble to 100 mM in DMSO and to 25 mM in Ethanol
Purity: >99%
CAS No: [141286-78-4]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Sekiguchi et al (1997) A novel allosteric potentiator of AMPA receptors: 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide. J.Neurosci. 17 5760. Sekiguchi et al (2001) The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment. Neuroreport 12 2974. Sekiguchi et al (2002) A desensitization-selective potentiator of AMPA-type glutamate receptors. Br.J.Pharmacol. 136 1033.
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    Keywords: PEPA, Ligand-gated Ion Channels, Allosteric Potentiator Of AMPA Receptor Desensitisation, Tocris Bioscience
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