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Category: EnzymesarrowKinasesarrowMAPK/MAPKK
Cat.No. Product Name
1213 PD 98059
Price and Availability

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PD 98059
Chemical Name: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

Biological Activity:

Specific inhibitor of mitogen-activated protein kinase kinase (MAPKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7 μM).

Technical Data:

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M.Wt: 267.28
Formula: C16H13NO3
Storage: Store at RT
Solubility: Soluble to 25 mM in DMSO and to 5 mM in Ethanol
Purity: >99%
CAS No: [167869-21-8]

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    References:

    Dudley et al (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc.Natl.Acad.Sci.USA 92 7686. Alessi et al (1995) PD 98059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J.Biol.Chem. 270 27489. Tsang et al (1998) Effects of mitogen-activated protein kinase kinase inhibitor PD 98059 on antigen challenge of guinea-pig airways in vitro. Br.J.Pharmacol. 125 61.
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    Keywords: PD 98059, Kinases, Specific Inhibitor Of MEK, PD98059, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    Function & Modulation of MAP Kinase Pathways
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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