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Category:
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7TM Receptors Peptides (Neuropeptides)Bombesin Receptors
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Cat.No.
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Product Name
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2603 |
PD 168368
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Price and Availability
Click here for full price details of
PD 168368
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Chemical Name:
(S)-a-Methyl-a-[[[(4-nitrophenyl)amino]carbonyl]amino]-
N-[[1-(2-pyridinyl)cyclohexyl]methyl]-1H-indole-3-propa
namide |
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Biological Activity:
Potent neuromedin B receptor antagonist (NMB-R,
BB1) (IC50 = 40 nM) that displays ~ 40-fold selectivity
over the gastrin-releasing peptide receptor (GRP-R, BB2) and >
300-fold selectivity over BRS-R (BB3). Antagonises neuromedin
B-stimulated calcium release and inhibits proliferation of rat glioma cells (IC50
= 2 μM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Ryan et al (1999)
Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD
168368. J.Pharmacol.Exp.Ther. 290 1202. Moody et al
(2000) Nonpeptide neuromedin B receptor antagonists inhibit the proliferation
of C6 cells. Eur.J.Pharmacol. 409 133. Moody et al
(2003) Nonpeptide gastrin releasing peptide receptor antagonists inhibit the
proliferation of lung cancer cells. Eur.J.Pharmacol. 474 21.
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or by Research Area
Keywords: PD 168368, Peptides (Neuropeptides), Selective Neuromedin B Receptor Antagonist (NMB-R, BB1), PD168368, Tocris Bioscience
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