PD 166793 | Proteases | Broad Spectrum Matrix Metalloproteinase (MMP) Inhibitor | PD166793

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Category:

Enzymes

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MMP

Cat.No.	Product Name
2520	PD 166793

Price and Availability

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PD 166793

Chemical Name: N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine

Biological Activity:

Broad spectrum matrix metalloproteinase (MMP) inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC₅₀values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.

Technical Data:

M.Wt:	412.3
Formula:	C₁₇H₁₈BrNO₄S
Storage:	Desiccate at +4°C
Solubility:	Soluble to 100 mM in DMSO and to 100 mM in Ethanol
Purity:	>99%
CAS No:	[199850-67-4]

Resources:

Certificate of Analysis / MSDS:

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References:

O'Brien et al (2000) Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available Biphenylsulfonamide matrix metalloproteinase inhibitors. J.Med.Chem. 43 156. Peterson et al (2001) Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure. Circulation 103 2303. Chancey et al (2002) Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload. Circulation 105 1983.

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Keywords: PD 166793, Proteases, Broad Spectrum Matrix Metalloproteinase (MMP) Inhibitor, PD166793, Tocris Bioscience

Literature in this Area

Signal Transduction Guide

	A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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Product Feature

MMP Inhibitors

Key MMP Inhibitors available from Tocris include:

2631 Marimastat

Broad spectrum MMP inhibitor

2621 ARP 100

Selective inhibitor of MMP-2

2633 WAY 170523

Selective inhibitor of MMP-13

View Product Feature

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