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Category:
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Enzyme-Linked Receptors Receptor Tyrosine Kinases (RTKs)EGFR
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Cat.No.
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Product Name
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2615 |
PD 158780
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Price and Availability
Click here for full price details of
PD 158780
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Chemical Name:
N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,
6-diamine |
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Biological Activity:
Potent inhibitor of erbB receptor
family tyrosine kinases (IC50 values are 0.008, 49 and 52 nM for
EGFR, erbB2 and erbB2/erbB4 respectively) that does not inhibit FGF or
PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest
in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma
cells.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Fry et
al (1997) Biochemical and antiproliferative properties of
4-[ar(alk)ylmino]pyridopyrimidines, a new chemical class of potent and specific
epidermal growth factor receptor tyrosine kinase inhibitor. Biochem.Pharmacol. 54
877. Sun et al (1999) Growth inhibition of nasopharyngeal
carcinoma cells by EGF receptor tyrosine kinase inhibitors. Anticancer Res. 19
919. Gonzales et al (2005) G1 cell cycle arrest due to inhibition
of erbB family receptor tyrosine kinases does not require the retinoblastoma
protein. Exp.Cell Res. 303 56.
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Keywords: PD 158780, Receptor Tyrosine Kinases (RTKs), Potent ErbB Receptor Family Inhibitor, PD158780, Tocris Bioscience
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Literature in this Area Cancer Research Guide | Our unique collection of more than 300 products related to cancer research, including the very latest exclusive research tools. | | Request Copy / View PDF |
Product Feature
Kinase Inhibitors
Key kinase Inhibitors available from Tocris include:
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