PD 153035 Hydrochloride | Receptor Tyrosine Kinases (RTKs) | EGFR-kinase Inhibitor | ZM 252868 | PD153035 Hydrochloride

Category:

Enzyme-Linked Receptors

Receptor Tyrosine Kinases (RTKs)

EGFR

Cat.No.

Product Name

1037

PD 153035 hydrochloride

Alternative name(s):

ZM 252868

PD 153035 hydrochloride C16H14BrN3O2.HCl 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride

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PD 153035 hydrochloride

Other Information:

Sold with the permission of AstraZeneca UK Ltd

Chemical Name: 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride

Biological Activity:

An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC₅₀ of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.

Technical Data:

M.Wt:	396.67
Formula:	C₁₆H₁₄BrN₃O₂.HCl
Storage:	Store at RT
Solubility:	Soluble to 10 mM in DMSO
CAS No:	[153436-54-5]

Resources:

Certificate of Analysis / MSDS:

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References:

Fry et al (1994) A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 265 1093. Bridges et al (1996) Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J.Med.Chem. 39 267. Bos et al (1997) PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin.Cancer Res. 3 2099.

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Keywords: PD 153035 Hydrochloride, Receptor Tyrosine Kinases (RTKs), EGFR-kinase Inhibitor, ZM 252868, PD153035 Hydrochloride, Tocris Bioscience

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