PCA 4248 | PAF Receptors | PAF Receptor Antagonist | PCA4248

Category:

Cat.No.	Product Name
0571	PCA 4248

Price and Availability

Click here for full price details of
PCA 4248

Chemical Name: 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid methyl 2-(phenylthio)ethyl ester

Biological Activity:

A specific PAF antagonist, more potent than the ginkolide BN-52021. Inhibits rabbit platelet aggregation with an IC₅₀ value of 1.05 μM and has no significant activity on Ca²⁺ channels. Active in vivo, antagonising PAF-induced systemic hypotension and protein-plasma extravasation in rats.

Technical Data:

M.Wt:	361.46
Formula:	C₁₉H₂₃NO₄S
Storage:	Desiccate at -20°C
Solubility:	Soluble to 100 mM in DMSO and to 100 mM in Ethanol
CAS No:	[123875-01-4]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

For specific/earlier batch please select:

References:

Sunkel et al (1990) 4-Alkyl-1,4-dihydropyridine derivatives as specific PAF-acether antagonists. J.Med.Chem. 33 3205. Sunkel et al (1990) 1,4-Dihydropyridines, a new class of platelet activating factor receptor antagonists: in vitro pharmacological studies. J.Pharmacol.Exp.Ther. 255 28. Fernandez-Gallardo et al (1990) Pharmacological actions of PCA 4248, a new platelet-activating factor receptor antagonist: in vivo studies. J.Pharmacol.Exp.Ther. 255 24.

View related products by Pharmacological Action or by Research Area

Keywords: PCA 4248, PAF Receptors, PAF Receptor Antagonist, PCA4248, Tocris Bioscience

New Product Guide

	Our latest New Product Guide highlights over 140 new products.
Request Copy / View PDF

Spring Specials

25% discount* on
selected Tocris products including:

Potent & selective NOP antagonist
Blocker of retinoic acid metabolism
Potent CCR1 receptor antagonist
Selective GnRH receptor antagonist
NMDA receptor antagonist

*Terms and conditions

New Products in this Area

	2940	PAF (C16)
	Endogenous platelet-activating factor (PAF)

for new product e-alerts

User ID
Password