PB 28 | Sigma & Imidazoline | High Affinity S2 Agonist | PB28

Category:

Cat.No.	Product Name
2562	PB 28 dihydrochloride

Price and Availability

Click here for full price details of
PB 28

Chemical Name: 1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-napht halenyl)propyl]piperazine dihydrochloride

Biological Activity:

High affinity σ₂ receptor agonist (K_i values are 0.8 and 15.2 nM for σ₂ and σ₁receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea-pig bladder and ileum (EC₅₀ values are 2.62 and 3.96 μM respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.

Technical Data:

M.Wt:	443.5
Formula:	_{C24H38N2O.2HCl}
Storage:	Desiccate at +4°C
Solubility:	Soluble to 20 mM in Water
Purity:	>99%
CAS No:	[172906-90-0]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Berardi et al (1996) New σ and 5-HT_1A receptor ligands: ω-(tetralin-1-yl)-n-alkylamine derivatives. J.Med.Chem. 39 176. Colabufo et al (2003) A new method for evaluating σ2 ligand activity in the isolated guinea-pig bladder. Naunyn-Schmied.Arch.Pharmacol. 368 106. Colabufo et al (2004) Antiproliferative and cytotoxic effects of some σ2 agonists and σ1 antagonists in tumour cell lines. Naunyn-Schmied.Arch.Pharmacol. 370 106.

View related products by Pharmacological Action or by Research Area

Keywords: PB 28, Sigma & Imidazoline, High Affinity S2 Agonist, PB28, Tocris Bioscience

New Product Guide

	Our latest New Product Guide highlights over 140 new products.
Request Copy / View PDF

First-Class Technical Expertise

At Tocris we understand that planning an experiment is complicated and that it is important to be able to interact with knowledgeable people who care about helping you find the products and information you need.

Our specialist scientists provide the highest level of service for every enquiry, fully researching each one and supplying the most accurate response, quickly.

We encourage our customers to contact us; no question is too small or insignificant.

New Products in this Area

	2669	TC 1
	High affinity σ₁ ligand
	2562	PB 28 dihydrochloride
	High affinity σ₂ agonist

for new product e-alerts

User ID
Password