|
Category:
|
Cellular Processes and Components ApoptosisApoptosis Inducer
|
|
Cat.No.
|
Product Name
|
|
2623 |
Oxaliplatin
|
| Alternative name(s): |
Eloxatin |
|
|
Price and Availability
Click here for full price details of
Oxaliplatin
|
|
Chemical Name:
Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II) |
|
|
Biological Activity:
Antitumour
agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA
crosslinks blocking DNA replication and transcription. Displays higher
cytotoxicity and lower nephrotoxicity than analogue cisplatin (Cat. No. 2251)
and shows antitumour activity in cell lines with acquired cisplatin resistance.
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
|
References:
Culy et al (2000) Oxaliplatin. A
review of its pharmacological properties and clinical efficacy in metastatic
colorectal cancer and its potential in other malignancies. Drugs 60
895. Raymond et al (2002) Cellular and molecular pharmacology of
oxaliplatin. Mol.Cancer Ther. 1 227. Mani et al
(2002) Oxaliplatin: a review of evolving concepts. Cancer Invest. 20
246.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: Oxaliplatin, Apoptosis, DNA Cross-linking Antitumour Agent, Eloxatin, Tocris Bioscience
|
|
Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
| “I am grateful for your honesty and courtesy. The principles of Tocris are very different to that of your competitors who, in fact, have put our inhibitor on the market without any approval, exhibiting a pirate policy and a total absence of ethics..” Researcher, University of Pisa, Italy |
|
