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Category:
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Enzymes ATPases/GTPasesATPase
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Cat.No.
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Product Name
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2583 |
Omeprazole
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Price and Availability
Click here for full price details of
Omeprazole
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Chemical Name:
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methy
l]sulfinyl]-1H-benzimidazole |
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Biological Activity:
H+,K+-ATPase
inhibitor (IC50 = 5.8 μM) that displays antisecretory and
antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.16 μM for histamine induced acid
formation) and reduces gastric lesion formation induced by a variety of
ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro. Also
blocks swelling dependent chloride channel (ICIswell) in NIH3T3 fibroblasts.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Satoh et al (1989) Antisecretory and anitulcer activities of a
novel proton pump inhibitor AG-1749 in dogs and rats. J.Pharmacol.Exp.Ther. 248
806. Richardson et al (1998) Proton pump inhibitors. Drugs 56
307. Schmarda et al (2000) The gastric H,K-ATPase blocker
lansoprazole is an inhibitor of chloride channels. Br.J.Pharmacol. 129
598.
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View related products by Pharmacological Action
or by Research Area
Keywords: Omeprazole, ATPases / GTPases, H+,K+-ATPase Inhibitor, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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