Olvanil | Transient Receptor Potential Channels | Potent Vanilloid Receptor Agonist | NE 19550

Category:

Ion Channels

Transient Receptor Potential Channels

TRPV

Cat.No.

Product Name

0934

Olvanil

Alternative name(s):

NE 19550

Price and Availability

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Olvanil

Chemical Name: N-Vanillyloleoylamide

Biological Activity:

Potent vanilloid receptor agonist (pEC₅₀ values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC₅₀ = 9 μM) and may bind to CB₁ cannabinoid receptors. Antinociceptive following systemic administration.

Technical Data:

M.Wt:	417.63
Formula:	C₂₆H₄₃NO₃
Storage:	Desiccate at -20°C
Solubility:	Soluble to 100 mM in DMSO and to 25 mM in Ethanol
Purity:	>99%
CAS No:	[58493-49-5]

Resources:

Certificate of Analysis / MSDS:

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References:

Dray et al (1990) NE-19550 and NE-21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail in vitro. Eur.J.Pharmacol. 181 289. Janusz et al (1993) Vanilloids. 1. Analogs of capsaicin with antinociceptive and antiinflammatory activity. J.Med.Chem. 36 2595. Di Marzo et al (1998) Interactions between synthetic vanilloids and the endogenous cannabinoid system. FEBS Lett. 436 449. Ralevic et al (2001) Cannabinoid activation of recombinant and endogenous vanilloid receptors. Eur.J.Pharmacol. 424 211.

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Keywords: Olvanil, Transient Receptor Potential Channels, Potent Vanilloid Receptor Agonist, NE 19550, Tocris Bioscience

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