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Category:
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7TM Receptors Dopamine ReceptorsDopaminergic-Related
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Cat.No.
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Product Name
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2599 |
OSU 6162 hydrochloride
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| Alternative name(s): |
PNU 96391 |
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Price and Availability
Click here for full price details of
OSU 6162
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Chemical Name:
(3S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine
hydrochloride |
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Biological Activity:
Dopamine stabiliser that lacks high in vitro
affinity for various neuroreceptors (Ki values are 447 and 1305 nM
for D2 and D3 receptors respectively and > 1 μM for other
targets). In vivo, shows high D2 receptor occupancy and is highly
active on dopamine synthesis and turnover. Induces stabilising effects on
psychomotor function in behavioural tests without inducing hypolocomotion or
catalepsy.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Nichols et al
(2002) PNU-96391A (OSU6162) antagonizes the development of behavioural
sensitization induced by dopamine agonists in a rat model for Parkinson's
disease. Neuropharmacology 43 817. Rung et al
(2005) The dopaminergic stabilizers (-)-OSU6162 and ACR16 reverse
(+)-MK-801-induced social withdrawal in rats.
Prog.Neuro-Psychopharm.Biol.Psychiat. 29 833. Natesan et
al (2006) The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine
[(-)-OSU6162] and 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine (ACR16) show
high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and
low potential for motor side effects in the rat. J.Pharmacol.Exp.Ther. 318
810.
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View related products by Pharmacological Action
or by Research Area
Keywords: OSU 6162, Dopamine Receptors, Dopamine Stabiliser, PNU 96391, OSU6162, Tocris Bioscience
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