ONO 4817 | Proteases | Broad Spectrum MMP Inhibitor | ONO4817

Category:

Cat.No.	Product Name
2628	ONO 4817

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ONO 4817

Chemical Name: N-[(1S,3S)-1-[(Ethoxymethoxy)methyl]-4-(hydroxyamino)-3 -methyl-4-oxobutyl]-4-phenoxybenzamide

Biological Activity:

Broad spectrum MMP inhibitor; K_i values are 0.45, 0.73, 1.1, 1.1, 2.1, 42 and 2500 nM for MMP-12, MMP-2, MMP-8, MMP-13, MMP-9, MMP-3 and MMP-7 respectively and IC₅₀ = 1600 nM for MMP-1). Displays no activity at other proteases up to a concentration of 100 μM. Exhibits antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma.

Technical Data:

M.Wt:	416.47
Formula:	C₂₂H₂₈N₂O₆
Storage:	Store at RT
Solubility:	Soluble to 100 mM in DMSO and to 50 mM in Ethanol
Purity:	>99%
CAS No:	[223472-31-9]

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Certificate of Analysis / MSDS:

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References:

Yamada et al (2000) ONO-4817, an orally active matrix metalloproteinase inhibitor, prevents lipopolysaccharide-induced proteoglycan release from the joint cartilage in guinea pigs. Inflamm.Res. 49 144. Muraishi et al (2001) Effect of a matrix metalloproteinase inhibitor (ONO-4817) on lung metastasis of murine renal cell carcinoma. Anticancer Res. 21 3845. Medina and Radomski (2006) Role of matrix metalloproteinases in intestinal inflammation. J.Pharmacol.Exp.Ther. 318 933.

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Keywords: ONO 4817, Proteases, Broad Spectrum MMP Inhibitor, ONO4817, Tocris Bioscience

Literature in this Area

Signal Transduction Guide

	A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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Product Feature

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