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Category:
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Cellular Processes and Components Cytoskeleton and Motor ProteinsMicrotubules
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Cat.No.
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Product Name
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1697 |
Noscapine hydrochloride
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Price and Availability
Click here for full price details of
Noscapine
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Chemical Name:
(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy
-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-iso
benzofuranone hydrochloride |
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Biological Activity:
Opioid
alkaloid with several actions. Binds to tubulin, arresting cells in mitosis and
inducing apoptosis. Also is an antagonist at bradykinin receptors (pA2 =
6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances
forskolin-stimulated increases in cAMP levels in CNS tissues. Clinically used
antitussive agent.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Mourey et al (1992) [3H]Noscapine
binding sites in brain: relationship to indoleamines and the phosphoinositide
and adenylyl cyclase messenger systems. Mol.Pharmacol. 42 619. Ye
et al (1998) Opium alkaloid noscapine is an antitumor agent that arrests
metaphase and induces apoptosis in dividing cells. Proc.Natl.Acad.Sci.USA 95
1601. Mahmoudian and Mojaverian (2001) Effect of noscapine, the
antitussive opioid alkaloid, on bradykinin-induced smooth muscle contraction in
the isolated ileum of the guinea-pig. Acta Physiol.Hung. 88 231. Landen
et al (2002) Noscapine alters microtubule dynamics in living cells and
inhibits the progression of melanoma. Cancer Res. 62 4109.
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Keywords: Noscapine, Cytoskeleton & Motor Proteins, Tubulin Inhibitor; Induces Apoptosis, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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