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5-Nonyloxytryptamine oxalate
Biological Activity:
5-HT1B selective agonist, several times more potent
than sumatriptan and inactive as a 5-HT1A agonist (Ki at
5-HT1B = 1 nM, selectivity over 5-HT1A > 300-fold).
Glennon et al (1994) 5-Nonyloxy)tryptamine: a novel high affinity-5-HT1Db
serotonin receptor agonist. J.Med.Chem. 37 2828. Glennon et
al (1996) Binding of O-Alkyl derivatives of serotonin at human 5-HT1Db
receptors. J.Med.Chem. 39 314.
Atypical antipsychotic agent that displays 5-HT2A receptor antagonism. Also displays high affinity at D2 receptors (Ki values are 0.4 and 3.13 nM for 5-HT2A and D2 receptors respectively).
