Nociceptin | Opioid Receptors | Endogenous ORL1 Agonist | Orphanin FQ

Category:

7TM Receptors

Opioid Receptors

Nociceptin (ORL1) Receptors

Agonists

Cat.No.

Product Name

0910

Nociceptin

Alternative name(s):

Orphanin FQ

Price and Availability

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Nociceptin

Biological Activity:

Endogenous ligand for the ORL₁ (Opioid Receptor-Like₁) member of the opioid receptor family (pK_i = 8.6). Has no significant activity at μ, δ or κ opioid receptors (pK_i < 6).

Technical Data:

M.Wt:	1808
Formula:	C₇₉H₁₂₈N₂₇O₂₂
Storage:	Desiccate at -20°C
Purity:	>99%
CAS No:	[170713-75-4]

Resources:

Certificate of Analysis / MSDS:

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References:

Meunier et al (1995) Isolation and structure of the endogenous agonist of opioid receptor-like ORL₁ receptor. Nature 377 352. Reinscheid et al (1995) Orphanin FQ: a neuropeptide that activates an opioid like G protein coupled receptor. Science 270 792. Henderson and McKnight (1997) The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ. TiPS 18 293. Guerrini et al (2000) Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A. Peptides 21 923.

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Keywords: Nociceptin, Opioid Receptors, Endogenous ORL1 Agonist, Orphanin FQ, Tocris Bioscience

Literature in this Area

Scientific Reviews

Opioid Receptors
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